[2S19a] Integrated Insights into GPCR Signal Transduction and Drug Discovery Prospects | The 98th Annual Meeting of the Japanese Biochemical Society

The 98th Annual Meeting of the Japanese Biochemical Society

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Symposium

[2S19a]Integrated Insights into GPCR Signal Transduction and Drug Discovery Prospects

Tue. Nov 4, 2025 1:00 PM - 3:00 PM JST
Tue. Nov 4, 2025 4:00 AM - 6:00 AM UTC

Room19(Room 554)

Organizers：Ryoji Suno（Department of Medicine, Kansai Medical University）, Hideaki Kato（University of Tokyo）

1:00 PM - 1:01 PM JST(4:00 AM - 4:01 AM UTC)

[2S19a-00]Introduction

^○Ryoji Suno (Department of Medicine, Kansai Medical University)

Comment()

1:01 PM - 1:24 PM JST(4:01 AM - 4:24 AM UTC)

[2S19a-01]A Rapid and Universal Pipeline for GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design

^○Hideaki Kato (The University of Tokyo)

キーテクノロジー：クライオ電子顕微鏡構造解析

Comment()

1:24 PM - 1:48 PM JST(4:24 AM - 4:48 AM UTC)

[2S19a-02]GPCR signaling regulation via membrane domains

^○Masataka Yanagawa^1,2 (1.Graduate School of Pharmaceutical Sciences, Kyoto University, 2.Riken CPR)

キーテクノロジー：Single-molecule imaging

Comment()

1:48 PM - 2:12 PM JST(4:48 AM - 5:12 AM UTC)

[2S19a-03]The New Paradigm in GPCR Drug Discovery: Harnessing Structure-Signal Relationships for Rational Drug Design

^○Tsuyoshi Saitoh^1,2,3 (1.Institute of Medicine, University of Tsukuba, 2.International Institute of Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 3.Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba)

キーテクノロジー：創薬

Comment()

2:12 PM - 2:36 PM JST(5:12 AM - 5:36 AM UTC)

[2S19a-04]Elucidation of GPCR signaling mechanisms using MD simulations

^○Ayori Mitsutake¹, Shun Yokoi² (1.Meiji University, 2.WPI-IIIS, TIAR, University of Tsukuba)

キーテクノロジー：分子シミュレーション

Comment()

2:36 PM - 2:59 PM JST(5:36 AM - 5:59 AM UTC)

[2S19a-05]Structural Insights into the Functional Selectivity of GPCR Ligands: Implications for Drug Discovery

^○Ryoji Suno (Department of Medicine, Kansai Medical University)

キーテクノロジー：cryo-EM SPA

Comment()

2:59 PM - 3:00 PM JST(5:59 AM - 6:00 AM UTC)

[2S19a-06]Closing Remarks

^○Hideaki Kato (The University of Tokyo)

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