[G] Biomaterials Development and Clinics(1)

3:50 PM - 4:05 PM JST(6:50 AM - 7:05 AM UTC)

[44] Machine learning models for predicting cellular responses to micro- and nanoplastics

○Hiroki Enokiya¹, Kousei Hatakeyama¹, Naoto Washihira¹, Mako Kobayashi¹, Sho Fujii², Tadao Tanabe³, Tsuyoshi Kimura⁴, Ikuro Suzuki⁵, Naoki Matsuda⁵, Masaya Yamamoto^1,6 (1. Graduate School of Engineering, Tohoku Univ., 2. Graduate School of Science, Yamagata Univ., 3. College of Engineering and Design, Shibaura Institute of Technology, 4. Faculty of Life Sciences, Toyo Univ., 5. Faculty of Engineering, Tohoku Institute of Technology, 6. Graduate School of Biomedical Engineering, Tohoku Univ.)

Keywords:

nanoplastic,microplastic,machine learning

PETマイクロ・ナノプラスチックの粒子径が細胞応答に及ぼす影響を機械学習で評価した。非溶媒相分離法で作製したPET粒子をTHP-1由来M1マクロファージに暴露し、IL-1β産生量とCD80発現量を測定することで得た学習データを用いてSVMモデルによる解析系を構築した。