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Mon. Mar 16, 2026

Tue. Mar 17, 2026

Wed. Mar 18, 2026

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Descending modulation of orofacial pain by insular cortical projections to brainstem nuclei

The neural pathways mediating pain transmission in the central nervous system remain an open issue, and understanding these neural circuits is essential for uncovering the mechanisms underlying chronic pain, including neuropathic and nociplastic pain. This symposium will introduce recent findings on the characteristics of neural circuits related to pain within the central nervous system, focusing particularly on the amygdala and cortical regions such as the anterior cingulate cortex, insular cortex, and prefrontal cortex, as well as their projection targets. Furthermore, we will discuss how modulation of neuronal activity within these brain regions influences pain-related behaviors, thereby providing up-to-date insights into the roles of higher-order brain areas in the processing of pain information.

ecent Advances in the Mechanisms of Nociceptive Information Processing in the Central Nervous System: From Higher-Order Neural Circuits to the Placebo Effect.

The 99th Annual Meeting of the Japanese Pharmacological Society

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[1-S-56]Descending modulation of orofacial pain by insular cortical projections to brainstem nuclei

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