Session Details
[1-S]ecent Advances in the Mechanisms of Nociceptive Information Processing in the Central Nervous System: From Higher-Order Neural Circuits to the Placebo Effect.
Mon. Mar 16, 2026 2:10 PM - 3:40 PM JST
Mon. Mar 16, 2026 5:10 AM - 6:40 AM UTC
Mon. Mar 16, 2026 5:10 AM - 6:40 AM UTC
Room 6(B202)
Chair:Masayuki Kobayashi(Department of Pharmacology Nihon University School of Dentistry), Yilong Cui(Hyogo Medical University, School of Medicine)
The neural pathways mediating pain transmission in the central nervous system remain an open issue, and understanding these neural circuits is essential for uncovering the mechanisms underlying chronic pain, including neuropathic and nociplastic pain. This symposium will introduce recent findings on the characteristics of neural circuits related to pain within the central nervous system, focusing particularly on the amygdala and cortical regions such as the anterior cingulate cortex, insular cortex, and prefrontal cortex, as well as their projection targets. Furthermore, we will discuss how modulation of neuronal activity within these brain regions influences pain-related behaviors, thereby providing up-to-date insights into the roles of higher-order brain areas in the processing of pain information.
[1-S-54]Synaptic Plasticity in the Lateral Parabrachial–Central Amygdala System and Its Role in Nociplastic sensitization
*Yukari Takahashi1, Takao Okuda1, Fusao Kato1 (1. Jikei University School of Medicine)
[1-S-55]Anterior cingulate cross-hemispheric projection to claustrum modulates pain-related behaviors
*Keisuke Koga1, Hidemasa Furue1 (1. Hyogo Med.l Univ.)
[1-S-56]Descending modulation of orofacial pain by insular cortical projections to brainstem nuclei
*Yuka Nakaya1, Masayuki Kobayashi1 (1. Nihon University School of Dentistry)
[1-S-57]Central mechanisms underlying placebo analgesia mediated by endogenous opioid signaling
*Yilong Cui1,2 (1. Hyogo Medical University, School of Medicine, 2. RIKEN Center for Integrative Medical Sciences)