Session Details
[2-SS1-01]Physiological functions of chalcogen super-complex and their medical applications
Tue. Mar 17, 2026 2:10 PM - 4:10 PM JST
Tue. Mar 17, 2026 5:10 AM - 7:10 AM UTC
Tue. Mar 17, 2026 5:10 AM - 7:10 AM UTC
Room 4(C200)
Chair:Motohiro Nishida(Kyushu University Graduate School of Pharmaceutical Sciences), Yasuo Watanabe(Showa Pharmaceutical University)
Life has evolved and developed along with efficient energy acquisition using bio-essential elements (oxygen (O), sulfur (S), and selenium (Se)) belonging to group 16 elements (chalcogens), which have excellent electron transfer capabilities. Although attention has focused only on the redox properties of each chalcogen, it has been revealed that O, S, and Se, together with bio-essential metals, form linear or cyclic super-complex molecules (bio-chalcogenides) in greater numbers than expected in living organisms, and that bio- chalcogenides exhibit active functions that cannot be explained by the individual elements. This symposium will present the latest findings on the unique functions of bio-chalcogenides and their potential in medical applications.
[2-SS1-01]Functional Roles of Mitochondrial Supersulfide Production
*Hozumi Motohashi1,2 (1. Graduate School of Medicine, Tohoku University, 2. Institute of Development, Aging and Cancer, Tohoku University)
[2-SS1-02]Mammals produce cyclo octasulfur to suppress ferroptosis
*Uladzimir Barayeu1,2 (1. Max Planck Institute for Polymer Research, 2. Tohoku University)
[2-SS1-03]Supersulfides-mediated mitochondrial energy metabolism and breath omics analysis
*Tetsuro Matsunaga1,2 (1. Comprehensive Center for Infectious Disease Control, Graduate School of Medicine, Akita University, 2. Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine)
[2-SS1-04]Regulation of the Supersulfide-Producing Enzyme Cystathionine γ-Lyase by Nitric Oxide-Derived Species
*Yukihiro Tsuchiya1, Shoma Araki1, Yasuo Watanabe1 (1. Showa Pharmaceutical University)
[2-SS1-05]Analysis of Supersulfide Metabolism Regulating Cardiac Robustness
*Akiyuki Nishimura1,2, Xiaokang Tang1,2, Liuchenzi Zhou1,2, Yuri Kato3, Motohiro Nishida1,2,3 (1. National Institute for Physiological Sciences, 2. Exploratory Research Center on Life and Living Systems, 3. Faculty of Pharmaceutical Sciences, Kyushu University)