Session Details
[1-S]Emerging Therapeutic Targets from Cutting-Edge Research on Radiation Effects
Mon. Mar 16, 2026 2:10 PM - 3:40 PM JST
Mon. Mar 16, 2026 5:10 AM - 6:40 AM UTC
Mon. Mar 16, 2026 5:10 AM - 6:40 AM UTC
Room 3(B200)
Chair:Osamu Kaminuma(Research Institute for Radiation Biology and Medicine, Hiroshima University), Akiko Nagamachi(The Foundation for Biomedical Research and Innovation at Kobe)
Radiation exerts diverse effects on living organisms, contributing to the development of cancer and other diseases. Building on the profound and tragic experiences, including the atomic bombings and the Fukushima Daiichi Nuclear Power Plant accident, Japan has become a global leader in radiation effects research, generating significant insights into the intricate molecular mechanisms involved. This symposium will bring together researchers at the forefront of these pioneering studies to identify novel therapeutic targets and explore their potential applications. Discussions will span a wide range of topics, from fundamental science to translational approaches, including cancer risk assessment, DNA damage repair, cellular signaling and epigenomic regulation, tumor microenvironment and treatment resistance, and advances in molecular imaging technologies. Our goal is to provide a dynamic forum that highlights cutting-edge research and opens new horizons for drug discovery.
[1-S-41]Hypoxia: the Hidden Driver of Cancer Genome Instability and Heterogeneity
*Hiroshi Harada1,2 (1. Graduate School of Biostudies, Kyoto University, 2. Radiation Biology Center, GSB, Kyoto University)
[1-S-42]Characteristics of Radiation Effects in Targeted Alpha Therapy and Their Applications to Drug Development
*Mikako Ogawa1 (1. Faculty of Pharmaceutical Sciences, Hokkaido University)
[1-S-43]Mechanistic insights into radiation-induced carcinogenesis using cancer-susceptible mouse models
*Megumi Sasatani1, Guanyu Zhou1, Tiancheng Liu1, Chaudhary Anupama 1 (1. Hiroshima University)
[1-S-44]Disruption of Hematopoietic Stem Cell Stress Response and the Pathogenesis of MDS: Insights from Radiation Biology
*Akiko Nagamachi1 (1. FBRI, Kobe)
[1-S-45]Histone modification and choice of DNA repair pathways
*Yuichiro Nakata1 (1. Graduate School of Medicine, Chiba University)
