Session Details
[1-S]Novel Therapeutic Targets of Irritable Bowel Syndrome in Brain and Gut
Mon. Mar 16, 2026 10:10 AM - 11:40 AM JST
Mon. Mar 16, 2026 1:10 AM - 2:40 AM UTC
Mon. Mar 16, 2026 1:10 AM - 2:40 AM UTC
Room 6(B202)
Chair:Akiyoshi Saitoh(Faculty of Pharmaceutical Sciences, TOKYO UNIVERSITY OF SCIENCE), Kenjiro Matsumoto(Doshisha Women’s College of Liberal Arts)
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. IBS is characterized by abdominal pain and altered bowel habits, including constipation, diarrhea or both. Psychological factors, the immune system, gut microbiota, epithelial permeability, intestinal motility, visceral sensing and altered brain-gut axis interactions have been linked to IBS. No treatment option fits all patients due to the pathogenesis and pathophysiology of IBS. In this symposium, we will introduce and discuss the novel candidates for IBS treatment that target delta-opioid receptor, transient receptor potential (TRP) channel, descending pain inhibitory pathways, and high mobility group box 1 (HMGB1).
[1-S-33]Role of transient receptor potential melastatin 8 in juvenile social defeat stress-induced irritable bowel syndrome-like symptoms
*Kenjiro Matsumoto1 (1. Doshisha Women’s College of Liberal Arts)
[1-S-34]Novel therapeutic potential of targeting HMGB1 in irritable bowel syndrome
*Maho Tsubota1, Atsufumi Kawabata1 (1. Kindai Univ.)
[1-S-35]How does stress cause defecation disorders? : Cross-talk between the descending pain modulatory pathway and the regulatory pathway for colorectal motility
*Yasutake Shimizu1,2 (1. Gifu University, Veterinary Physiology, 2. Center for One Medicine Innovative Translational Research (COMIT), Institute for Advanced Study, Gifu University)
[1-S-36]Therapeutic Potential of Targeting Opioid δ-Receptors Based on Brain–Gut Interaction in Irritable Bowel Syndrome
*Akiyoshi Saitoh1, Toshinori Yoshioka1, Daisuke Yamada1 (1. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, TOKYO UNIVERSITY OF SCIENCE)