[20a-A305-1~9] 3.3 Biomedical optics (formerly 3.4)

9:45 AM - 10:00 AM JST(12:45 AM - 1:00 AM UTC)English Presentation

[20a-A305-4] Computational-hardware hybrid methods for tissue deep imaging in Jones matrix polarization-sensitive optical coherence tomography

〇(DC)Lida Zhu¹, Shuichi Makita¹, Junya Tamaoki², Antonia Lichtenegger³, Yiqiang Zhu¹, Makoto Kobayashi², Yoshiaki Yasuno¹ (1.Computational Optics Group, University of Tsukuba, 2.Department of Molecular and Developmental Biology, University of Tsukuba, 3.Center for Medical Physics and Biomedical Engineering, Medical University of Vienna)

Keywords:

PS-OCT,Multiple scattering,Computational refocusing

We developed computational-hardware-hybrid methods for deep imaging in polarization-sensitive optical coherence tomography (PS-OCT). The hybrid methods removes the trade-off between lateral resolution and depth-of-focus and reduced the multiple-scattering signal in deep regions. Experimental results on porcine muscle and medaka fish demonstrated improved resolution, visualization of fiber structures, and enhanced image contrast. The proposed methods have important implications for PS-OCT imaging of thick biological tissues, making it a more practical and powerful modality for tissue imaging.