[21a-A305-1~10] 2.2 Radiation physics fundamentals & applications, radiation generators, new technology

11:00 AM - 11:15 AM JST(2:00 AM - 2:15 AM UTC)

[21a-A305-8] Suppression of activation of specific elements in drug molecules for activation imaging

〇Nanase Koshikawa¹, Yuka Kikuchi¹, Jun Kataoka¹, Tomohiro Kobayashi², Yasuo Wakabayashi², Atsushi Toyoshima³, Yuichiro Kadonaga³ (1.Waseda Univ., 2.RIKEN, 3.Osaka Univ.)

Keywords:

Activation imaging,Visualization of drugs,Neutron activation

For visualization of pharmacokinetics, we have proposed a method of neutron activation of Pt atoms in the cisplatin [Pt(NH3)2Cl2], which is an anticancer drug, and imaging with gamma rays. However, when cisplatin is irradiated with neutrons, not only Pt atoms but also Cl atoms are activated. The activated Cl atoms emit high-energy gamma rays and are likely to break chemical bonds in the molecule. In this presentation, we will talk about the suppression of the activation of Cl atoms in cisplatin by using a Cd/Gd filter.