[17p-C31-1~20] 12.7 Biomedical Engineering and Biochips

1:45 PM - 2:00 PM JST(4:45 AM - 5:00 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation AwardEnglish Presentation

[17p-C31-4] Design and Fabrication of Deep Trench Probe for Lactate Sensing to Analyze Cancer Cells in Brain Tissue

〇(M2)Shinki Kyuu¹, Naoki Iwanuma¹, Shutaro Oba¹, Kazushi Tsuji², Takafumi Fukushima^1,2, Tetsu Tanaka^1,2 (1.TOHOKU Univ., 2.Tohoku Univ.)

Keywords:

bio sensor,lactate sensor

Glioblastoma multiforme (GBM) is a highly lethal grade IV brain tumor. Despite standard treatment like surgery, the 5-year survival rate remains only 7.2%. The infiltrative nature of GBM makes complete resection at the cellular level extremely challenging. Due to the Warburg Effect, elevated lactate levels in brain tissue are a key indicator of the presence of cancer cells. A proposed brain-implantable probe aims to help define tumor boundaries during surgery by detecting lactate levels in real-time with high precision.