[19a-C32-1~8] CS.12 Code-sharing Session of 12.6 & 12.7

10:00 AM - 10:15 AM JST(1:00 AM - 1:15 AM UTC)

[19a-C32-4] Surface plasmon hydrogel aptasensor for sensitive and real-time measurement of vancomycin

〇Koji Toma¹, Yui Taguchi², Kenta Iitani², Takahiro Arakawa³, Kohji Mitsubayashi² (1.Shibaura Inst. of Technology, 2.Tokyo Medical and Dental Univ., 3.Tokyo Univ. of Technology)

Keywords:

biosensor,drug,continuous measurement

Vancomycin (VCM), an effective treatment for methicillin-resistant Staphylococcus aureus infections, has a narrow therapeutic window (trough levels: 6.4–13.5 μM) and poses a risk of acute kidney injury at high concentrations. Current latex immunoturbidimetric methods can only provide single-point measurements, relying on intermittent testing. In this study, we aimed to achieve high-sensitivity and real-time measurement of VCM by developing a surface plasmon hydrogel aptasensor. This sensor utilizes surface plasmon polaritons effectively by immobilizing peptide aptamers within a three-dimensional hydrogel matrix.