[19p-C32-1~12] 3.3 Biomedical optics

3:45 PM - 4:00 PM JST(6:45 AM - 7:00 AM UTC)English Presentation

[19p-C32-11] Dynamic optical coherence tomography to assess the swiftness of intratissue activities

〇(D)Rion Morishita¹, Pradipta Mukherjee^1,2, Ibrahim Abd El-Sadek^1,3, Tanatchaya Seesan⁴, Tomoko Mori⁵, Atsuko Furukawa⁵, Satoshi Matsusaka⁵, Shuichi Makita¹, Yoshiaki Yasuno¹ (1.COG, Univ. of Tsukuba, 2.IIT Delhi, 3.Damietta Univ., 4.KMITL, 5.Univ. of Tsukuba Med.)

Keywords:

optical coherence tomography,dynamics imaging,in vitro sample

We introduce a dynamic optical coherence tomography (DOCT) method to assess the speed of the intratissue activities of in vitro samples. The DOCT method is based on the computation of time variance of the dB-scaled OCT intensity. An analysis of the acquisition-time dependency of the time variance provides two DOCT contrasts simultaneously. The relationship between each DOCT contrast and scatterer motion was numerically investigated. In addition, a human breast cancer spheroid was investigated with the DOCT method, which clarified the scatterer-motion properties in the sample.