[20a-P03-1~29] 12.6 Nanobiotechnology

[20a-P03-6] Single-Molecule L-DOPA/Dopamine Discrimination under Acidic Condition

Jiho Ryu¹, 〇Yuki Komoto¹, Takahito Ohshiro¹, Masateru Taniguchi¹ (1.Osaka Univ. SANKEN)

Keywords:

Single-molecule measurement,Break Junction,Machine learning

L-dopa is a neurotransmitter of interest for its interaction with dopamine, and a method to selectively detect it is desired. We focused on single-molecule measurement and conducted experiments to develop a method to detect and discriminate between L-dopa and dopamine. pH7 measurements at pH7 did not discriminate between the signals of the two molecules because their conductances were close. pH3 measurements increased the current of L-dopa and decreased that of dopamine. The two molecules were successfully discriminated with an accuracy of 0.74.