Presentation Information
[23a-1BM-11]Microelectronic Fiber Sensors for Multiplexed Neurochemical Sensing via Electrografting and Click Chemistry
〇(B)Tomoki Saizaki1, Satomi Ishikawa1, Yuanyuan Guo1 (1.FRIS, Tohoku Univ.)
Keywords:
biosensors,fibers,electrochemical sensing
Globally, brain disorders impact billions. Search for effective therapies requires a mechanistic understanding of neural dynamics from molecular to circuit and behavior levels. Existing technologies lack the capabilities to dynamically monitor in-brain intrinsic chemistry. In this study, to measure multiple chemicals in the brain with high sensitivity and selectivity, we fabricated an aptamer-coupled fiber sensor with four carbon composite electrodes via thermal drawing technology. In particular, we developed a surface modification method using electro-addressing, an electrochemical technique to immobilize aptamer probes on the fiber electrode surface. The newly developed fiber sensor for multiplexed sensing of neurochemicals such as dopamine and serotonin can advance the mechanistic understanding of neuropsychiatric disorders and thus propel the development of novel diagnostic and therapeutic methods.