[23a-1BN-1~10] 12.6 Nanobiotechnology

9:45 AM - 10:00 AM JST(12:45 AM - 1:00 AM UTC)

[23a-1BN-4] Evaluation of ion permeability of lipid bilayer in giant unilamellar vesicles

〇Yuto Yoshinare¹, Azusa Oshima², Masumi Yamaguchi², Akira Heya¹, Koji Sumitomo¹ (1.Univ. of Hyogo, 2.NTT Basic Res. Labs., BMC)

Keywords:

giant unilamellar vesicles,ion permeability

Giant vesicles (GUVs) are spherical lipid bilayers, the basic structure of human cell membranes, and are often used as reaction sites for biomembrane mimicry. The bilayer separates the inside and outside of the cell, and the difference in ion concentrations generated there is an important factor in the expression of biological functions. In this study, we focused on protons, which are considered to have a relatively large membrane permeability coefficient, and attempted to evaluate the proton permeability of GUVs and the membrane potential generated in lipid bilayers.