Presentation Information
[23p-1BN-9]Tear cholesterol sensor on a contact lens
〇(M2)Lin Zhuo1, Yang Cui1, Saman Azhari1, Takeo Miyake1 (1.Waseda Univ.)
Keywords:
cholesterol,biosensor,contact lens
Cholesterol is a lipid that is essential for the physiological functions of the human body. However, high cholesterol levels (over 5.7mM in the blood), especially elevated low-density lipoprotein cholesterol (LDL-C, commonly known as "bad" cholesterol), are closely related to the onset or progression of cardiovascular diseases. When LDL-C levels are over 2.6mM in blood, cholesterol can build up in the artery walls and gradually form plaques. These plaques can lead to narrowing and hardening of blood vessels, ultimately affecting blood flow and increasing cardiovascular disease risk. It is important to note that cholesterol also includes high-density lipoprotein cholesterol, which is protective of cardiovascular health because it helps remove excess cholesterol from the arteries. Therefore, understanding overall cholesterol levels is essential to assessing the risk of cardiovascular disease. There is a correlation between total cholesterol levels in tears and blood cholesterol levels[1], and measurement of free cholesterol provides a more direct reflection of the metabolic state in an organism, especially the physiological conditions associated with hyperlipidemia.
In this study, we propose a noninvasive smart contact lens based on cholesterol monitoring in tears. Targeting a wireless power supply technology utilizing magnetic field resonance coupling, an electrochemical cholesterol biosensor was integrated by combining a parallel-type LCR resonator and an enzyme electrode as followed by our previous works[2]. Our biosensor can selectively detect free cholesterol from 0.1mM to 1.4mM in artificial tear fluid by using cholesterol oxidase biocatalyst with Os-based mediator coupling. The results include important clinical and scientific implications for the future development of tear fluid-based biomarker monitoring systems and for understanding the relationship between cholesterol and cardiovascular health.
In this study, we propose a noninvasive smart contact lens based on cholesterol monitoring in tears. Targeting a wireless power supply technology utilizing magnetic field resonance coupling, an electrochemical cholesterol biosensor was integrated by combining a parallel-type LCR resonator and an enzyme electrode as followed by our previous works[2]. Our biosensor can selectively detect free cholesterol from 0.1mM to 1.4mM in artificial tear fluid by using cholesterol oxidase biocatalyst with Os-based mediator coupling. The results include important clinical and scientific implications for the future development of tear fluid-based biomarker monitoring systems and for understanding the relationship between cholesterol and cardiovascular health.