Presentation Information
[24a-1BN-4]Rapid measurement of cytokine over wide concentration range in small amount of sample with micro-flow optical condensation
〇(B)Kosei Takemori1,2,3,4, Koki Komori2,3,4, Yumiko Takagi3,2, Mamoru Tamura5,3, Ikuhiko Nakase2,3, Shiho Tokonami4,3, Takao Kobayashi6,3, Sota Iwatani6, Masaaki Murakami7,8,9, Takuya Iida1,2,3,4 (1.Clg. Life Env. Adv. Osaka Pref. Univ., 2.Grad. Sch. Sci. in Osaka Met. Univ., 3.RILACS in Osaka Met. Univ., 4.Grad. Sch. Eng. in Osaka Met. Univ., 5.Grad. Sch. Sci. Eng. in Osaka Univ., 6.Hyogo Pref. Kobe Child. Hosp., 7.IGM, Hokkaido Univ., 8.Nat. Inst. Quantum & Radiological Sci. & Technol (QST), 9.Nat. Inst. Physiol Sci.)
Keywords:
cytokine,microchannel,optical condensation
If a cytokine as the protein associated with inflammatory reactions could be measured in a small amount of liquid sample, it could make a significant contribution to blood testing of preterm infants. In this study, we demonstrated the possibility of rapid and selective detection of cytokines with a wide range of concentrations over several orders of magnitude in a µL-level sample using microflow optical condensation, which enables highly efficient antigen-antibody reaction by the synergistic effects of pressure-driven flow in a microfluidic channel and optical pressure from a laser.