Presentation Information
[10a-N104-8]Experimental investigations of dependence of the diameter of scatterers on circularly polarization of light scattered from biological tissues
〇Mike Raj Maskey1, Yoshimasa Ito1, Kyosuke Murata1, Koki Kasama1, Asato Esumi1, Takahiro Kuchimaru2, Nozomi Nishizawa1 (1.Kitasato Univ., 2.Jichi Med. Univ.)
Keywords:
Circularly polarized light,Optical biopsy,Light scattering
It is known that when circularly polarized light is irradiated onto a scattering medium, the degree of circular polarization (DOCP) of the scattered light is varied according to the particle size of the scatterers. Computational calculations in which cell nuclei are regarded as scatterers have concluded that changes in DOCP values of light scattered from biological tissues is due to the size of cell nuclei. However, the contributions of other scatterers have been ignored in these calculations, although the biological tissues consist of various particles. In this study, we prepared a biological phantom with a spot of larger scatterers in a matrix of smaller scatterers. By comparing the DOCP values of light scattered by the phantom and the metastatic cancer tissue, we experimentally demonstrate that changes in the DOCP values in biological tissue are caused by size variations of cell nuclei, not by other contributions of other scatterers.