[10p-N104-1~10] 3.3 Biomedical optics

4:00 PM - 4:15 PM JST(7:00 AM - 7:15 AM UTC)

[10p-N104-10] Non-invasive real-time prediction of glioblastoma DNA methylation status
– Blood lipid characteristics captured by infrared absorption spectra –

〇Saiko Kino¹, Masayuki Kanamori², Yuji Matsuura¹ (1.Graduate School of Biomedical Engineering, Tohoku Univ., 2.Graduate School of Medicine, Tohoku Univ.)

Keywords:

FTIR-ATR,plasma,glioblastoma DNA methylation

The methylation rate of the MGMT promoter region of glioblastoma DNA significantly influences prognosis prediction and treatment decisions. Aiming for minimally invasive real-time measurement from peripheral blood, infrared absorption spectra measurements were performed on patient plasma. This measurement does not require specific reagents or sample pretreatment. We describe the ability to distinguish methylation status based on multivariate analysis of the spectra, as well as changes in glioblastoma lipid metabolism and observed blood lipid characteristics associated with methylation rates.