[10a-C309-1~13] 12.7 Biomedical Engineering and Biochips

10:00 AM - 10:15 AM JST(1:00 AM - 1:15 AM UTC)

[10a-C309-5] Intracellular action potential recording using micro organic electrochemical transistors

〇Yasutoshi Jimbo¹, Sunghoon Lee¹, Wonryung Lee¹, Takashi Ohya², Hassani Faezeh¹, Tomoyuki Yokota¹, Katsuhisa Matsuura³, Shinjiro Umezu², Tatsuya Shimizu³, Takao Someya¹ (1.Univ. of Tokyo, 2.Waseda Univ., 3.TWMU)

Keywords:

semiconductor,action potential,Cell

Recording action potentials from cardiomyocytes is a promising application for biocompatible organic electrochemical transistors (OECTs). While conventional microelectrode arrays (MEAs) can measure extracellular potentials, it has been difficult to obtain actual action potential waveforms derived from the cell membrane potential itself. We previously reported a method to induce electroporation in the cell membrane by driving an OECT with a pulsed voltage, thereby recording waveforms that reflect the membrane potential [1]. Here, we report that the OECT geometry may dectate the density of the current flowing into the cells, potentially influencing the intensity of electroporation.[1] Y. Jimbo et al., Proc. Natl. Acad. Sci., doi:10.1073/pnas.2022300118, (2021).