[10a-E308-1~9] 6.6 Probe Microscopy

10:45 AM - 11:00 AM JST(1:45 AM - 2:00 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[10a-E308-8] Stabilizing t-SPESI Mass Spectrometry Imaging through Dual-Feedback Control of an Oscillating Capillary Probe

〇(M2)Takao Yasuda¹, Yoichi Otsuka¹, Michisato Toyoda¹ (1.Graduate School of Science, Univ. Osaka)

Keywords:

Mass spectrometry imaging

We have developed tapping-mode scanning probe electrospray ionization (t-SPESI), which extracts and ionizes sample components using an oscillating quartz capillary probe and a small amount of solvent, and have applied it to mass spectrometry imaging (MSI) of biological tissues. However, during long-term measurements, temporal fluctuations in the oscillation phase and amplitude of the probe have been observed. In this study, we introduced a dual-feedback control system and evaluated its effectiveness in long-term MSI.