Presentation Information
[10p-B32-5]Single-molecule tunneling measurements for discrimination of neurotransmitters and sensing of intermolecular interactions
〇Yuki Komoto1 (1.Osaka Univ. SANKEN)
Keywords:
Single-molecule measurement,Break Junction,Machine learning
Understanding brain function requires measurements of electrical activity, blood flow, anatomical structure, and chemical information. Among these, neurotransmitters play a central role in synaptic communication, and their direct detection provides valuable insights into neural circuit function. However, achieving high temporal resolution, spatial resolution, and molecular selectivity simultaneously remains challenging.In this presentation, we introduce single-molecule tunneling current measurements as a novel approach for chemical sensing. This technique measures transient tunneling currents through individual molecules trapped between nanogap electrodes, enabling highly sensitive molecular identification. I will present thestudies on neurotransmitter discrimination, molecular detection in complex environments containing interfering species, and the identification of intermolecular interactions at the single-molecule level.