Presentation Information
[11a-N304-11]Interfacial Residue Distribution Effects on Electronic-State Modulation at Protein-2D material Interfaces
〇Natsumi Ishida1, Daisuke Kiriya1 (1.The Univ. of Tokyo)
Keywords:
TMDC,MoS2,Protein
Direct protein-two dimensional semiconductor interactions remain largely unexplored, despite their importance for understanding bioelectronic interfaces. Two-dimensional semiconductors exhibit high sensitivity of their electronic properties to interfacial perturbations. In conventional discussions of protein-induced electrostatic effects, the response is mainly explained by charge sign reversal of protein net charge. However, due to this high sensitivity, local residue charge distributions at the contact interface may play a more significant role than the net charge.
In this presentation, we discuss protein-induced electronic-state modulation in MoS2 FETs through electrical measurements and calculations based on PDB-derived orientation sampling. For each configuration, the total charge of the residues in contact regions is evaluated, and the relationship between net charge, interfacial residue charge distributions, and the observed electronic-state modulation is discussed.
In this presentation, we discuss protein-induced electronic-state modulation in MoS2 FETs through electrical measurements and calculations based on PDB-derived orientation sampling. For each configuration, the total charge of the residues in contact regions is evaluated, and the relationship between net charge, interfacial residue charge distributions, and the observed electronic-state modulation is discussed.