Presentation Information
[11a-PA4-10]Feasibility study of early diffuse cancer detection by circularly polarized light scattering using biological phantoms
〇(B)Momoka Yamaguchi1, Mike Raj Maskey1, Koki Kasama1, Iori Maeda2, Nozomi Nishizawa1 (1.Sch. of Sci., Kitasato Univ., 2.Sch. of Medical Sci., Kitasato Univ.)
Keywords:
Circularly polarized light,Optical biopsy,Diffuse cancer
Circularly polarized light irradiated onto biological tissue undergoes multiple scattering with the cell nuclei and depolarization. Since the depolarization intensity depends on the wavelength and the particle size of the scatterers, information about the scatterers can be obtained from the polarization state of the scattered light. This circularly polarized light scattering method can detect changes in the size and content of scatterers by appropriately selecting the wavelength, making it a promising tool for evaluating diffuse cancer, which is currently difficult to detect at an early stage. We report on the validation of this technique’s effectiveness for diffuse cancer evaluation using aqueous suspension samples with various content ratios of particles of different sizes imitating healthy and cancerous cell nuclei.