Presentation Information
[11a-PA4-12]Evaluation of neuronal injury based on structural changes in plasma proteins using mid-infrared spectroscopy
〇Saiko Kino1, Tomohisa Ishida2, Masayuki Kanamori2, Kuniyasu Niizuma2, Yuji Matsuura1 (1.Graduate School of Biomedical Engineering, Tohoku Univ., 2.Graduate School of Medicine, Tohoku Univ.)
Keywords:
FTIR-ATR,neurology,plasma
Tau and neurofilament light chain (NfL), blood biomarkers of neuronal injury, exist at extremely low concentrations and require high-sensitivity measurements, making them unsuitable for screening. In this study, plasma samples from patients with neurological disorders associated with neuronal injury were analyzed using mid-infrared spectroscopy, with a focus on protein structural changes. The β-sheet/α-helix ratio and discriminant analysis revealed the potential to detect continuous structural variations associated with neuronal injury.