Presentation Information
[11a-PA4-9]Estimation of optical coefficients of biological phantom using integrating sphere measurement and inverse Monte Carlo method
〇(M1)Iori Maeda1, Mike Raj Maskey2, Koki Kasama2, Toshihide Matsumoto1, Nozomi Nishizawa2 (1.Grad. Sch. of Med. Sci., Kitasato Univ., 2.Sch. of Sci.,Kitasato Univ.)
Keywords:
Light scattering,inverse Monte Carlo method,Optical properties
The Circularly Polarized Light Scattering (CiPLS) method uses depolarization of circularly polarized light with multiple scattering to detect cancerous tissues with enlarged cell nuclei. This method is particularly promising for detecting early-stage and precursor lesions of cervical cancer, which are challenging to diagnose with current techniques. Due to the scarcity of specimens with these lesions, systematic validations are ongoing. We verify the method's feasibility using biological phantoms that imitate these early-stage lesions. When using biological Phantoms, it is necessary to evaluate the reproducibility of optical properties. In this study, we estimate the optical coefficients of the biological phantom by measuring transmittance and reflectance with an integrating sphere and applying Inverse Monte Carlo method.