[8a-C214-1~13] 12.6 Nanobiotechnology

9:00 AM - 9:15 AM JST(12:00 AM - 12:15 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[8a-C214-1] Improvement of Ion Current Signal-to-Noise Ratio for ssDNA Translocation Detection Using Solid-State ELGP Nanopores

〇Kosuke Wakabayashi¹, Toshiki Ogawara¹, Shota Gamo¹, Zhengze Guo¹, Yoh Onozawa¹, Minoru Yano², Seiichiro Izawa¹, Yohei Sasagawa², Itoshi Nikaido², Yutaka Majima¹ (1.Science Tokyo MSL., 2.Science Tokyo MRI.)

Keywords:

nanopore,DNA sequencer,nanotechnology

Solid-state nanopores enable long-read DNA sequencing with high durability, but their rapid translocation speed limits signal resolution. We previously fabricated nanometer-sized gold nanopores using our unique electroless gold plating (ELGP) method, achieving a reduced ssDNA translocation speed of ~140 nt/s. To enable base sequencing, this study evaluates the noise components of ionic current signals and explores approaches to improve the S/N ratio.