[8a-C309-1~13] 12.7 Biomedical Engineering and Biochips

9:30 AM - 9:45 AM JST(12:30 AM - 12:45 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[8a-C309-3] Proof of Aptamer Competitive Assay for Protein Detection Using Solution-gated ITO-based Thin-Film Transistor

〇(M2)Ken Takashima¹, Ritsu Naganuma¹, Toshiya Sakata¹ (1.Graduate School of Engineering, The University of Tokyo)

Keywords:

Aptamer Competitive Assay,Solution Gate Transistor,Protein

This study investigated the detection of glycated albumin (GA), a diabetes biomarker, using a semiconductor indium tin oxide (ITO) thin-film transistor (TFT). A competitive assay was implemented by utilizing hybridization between a probe DNA immobilized on the ITO surface and a GA aptamer. Measurements performed at GA concentrations of 10–50 nM showed that the gate-voltage shift (ΔVg) decreased with increasing GA concentration, demonstrating a clear concentration-dependent response. These results confirm the feasibility of quantitative GA detection using the proposed ITO-TFT biosensor.