[8p-E311-1~19] 8.4 Plasma life sciences

3:30 PM - 3:45 PM JST(6:30 AM - 6:45 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[8p-E311-8] Correlation between Dynamic Properties and Temperature-Dependent Hydrogen Peroxide Permeability of Phospholipid Bilayers: An MD Study

〇(M2)Yuki Iijima¹, Ippei Yagi¹, Kosuke Tachibana², Akinori Oda³, Takehiko Sato⁴, Satoshi Uchida¹ (1.Tokyo Metropolitan Univ., 2.Oita Univ., 3.Chiba Inst. of Tech., 4.Tohoku Univ.)

Keywords:

Plasma medicine,Membrane permeability,Lipid phase transition

To elucidate the mechanisms of plasma medicine, we performed MD analysis on the effect of temperature-dependent phase transitions on H₂O₂ permeability in major phospholipid films (POPC, POPE, PSM, etc.). We found that in POPE and PSM, the permeability coefficient dramatically improved with the phase transition (from gel to liquid crystal phase). These results suggest that the phase state (dynamic properties) of the film is the main factor determining the permeability, and that dynamic control of the active species dosage by controlling the external temperature is possible.