Presentation Information

11:15 AM - 11:30 AM JST(2:15 AM - 2:30 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[9a-C309-9]Fabrication of a Highly Sensitive Si Nanowire (NW) Biosensor for the Early Diagnosis of Infectious Diseases and the Detection of Anti-Influenza Virus Antibody

〇Ryuto Fukushima¹, Fumiya Osawa¹, Haru Okamoto¹, Noriyasu Ohshima¹, Taira Kajisa², Toshiya Sakata³, Izumi Takashi⁴, Sone Hayato¹, Hui Zhang¹ (1.Gunma Univ., 2.SympaFit Inc., 3.The Univ. of Tokyo5, 4.Teikyo Heisei Univ)

Keywords:

Silicon Nanowires,Ultrasensitive,Biosensor

A highly sensitive silicon nanowire (SiNW) biosensor was fabricated for the early diagnosis of infectious diseases, and its capability to detect anti-influenza virus antibodies (anti-HA1 IgG) was investigated. In addition to optimizing the SiNW structure and dopant concentration, a molecular recognition interface was designed based on thiol-covalent immobilization of HA1. Real-time current measurements demonstrated a clear sensor response corresponding to increasing anti-HA1 IgG concentrations, and detection was successfully achieved at concentrations as low as 10 aM.

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