[9p-N302-1~9] Fostering Disruptive Thinking and Research Approaches in Photonics

2:35 PM - 3:05 PM JST(5:35 AM - 6:05 AM UTC)

[9p-N302-4] A Novel Approach Beyond the Limits of Light for Medicinal Chemistry

〇Mikako Ogawa^1,2 (1.Hokkaido Univ, 2.WPI-ICReDD)

Keywords:

photon,Medicinal Chemistry

Photocaged compounds are widely used in life science research; however, their application in humans remains challenging because light cannot penetrate deep tissues efficiently. To overcome this limitation, we developed a molecular activation strategy using hard X rays, which possess high tissue penetrability. Through this work, we identified chemical structures that selectively react with hydrated electrons generated by X ray irradiation and successfully created X ray responsive caged compounds. In this lecture, I will discuss the original concept, the reaction mechanism, and the potential future medical applications of this technology.