Presentation Information
[15a-PA1-3]Intracellular Pathway Analysis of Activity Changes in NKT-like Cells Induced by Plasma Irradiation
〇Daiki Takeshita1, Yoshihito Yagyu1, Hayashi Nobuya1, Aijima Reona2, Yamashita Yoshio2 (1.Kyushu Univ., 2.Saga Univ.)
Keywords:
Atmospheric pressure oxygen plasma,Immune cells
Atmospheric pressure oxygen plsma was evaluated for its potential to modulate functional programs of NKT-like EL-4 cells.After plama irradiation, representative transcription factors (Tbet and GATA3) and per-cell cytokine production (IFNγ, TNFα, and IL4) were assessed as readouts of NKT1- and NKT2-like responses. Gene expression analysis was further conducted to estimate the associated signaling pathways.