Presentation Information
[15a-WL1_201-4]Pressure-Driven Flow for DNA Molecular Measurements Using Solid-State Nanopores
〇(M1)Shu Takahashi1, Hirohito Yamazaki1 (1.Nagaoka Univ. of Tech.)
Keywords:
Solid-State Nanopores,DNA Single-Molecule Detection,Pressure Gradient
Nanopore sensing has attracted attention in the medical and pharmaceutical fields as a high-resolution, label-free molecular detection technology. In our laboratory, a single solid-state nanopore can be fabricated using a unique processing method that combines laser etching and voltage-induced dielectric breakdown (photothermal etching-assisted controlled dielectric breakdown). In conventional nanopore measurements, electrophoresis is the primary driving force for molecular transport, which makes it difficult to analyze proteins with non-uniform charge states. To address this issue, we propose a protein identification method that employs pressure-driven flow as a novel driving force. In this presentation, we report the results of introducing pressure-driven flow for DNA detection.