[16a-PB7-1~2] 3.14 Optics and Photonics English Session

English Presentation

[16a-PB7-1] Rapid Protein Detection by Surface-Enhanced Raman Scattering Using a Gold Nanotriangular Array on Xerogel

〇(DC)Tianxu Gao¹, Kuniharu Ijiro², Hideyuki Mitomo² (1.Grad. Sch. of Life Sci., Hokkaido Univ., 2.RIES, Hokkaido Univ.)

Keywords:

Surface-enhanced Raman Scattering,Molecular Detection,Gold Nanoparticle

Surface-enhanced Raman scattering (SERS) is a powerful tool for label-free and sensitive molecular detection, utilizing localized-enhanced optical fields in metallic nanogaps. However, conventional SERS substrates are not suitable for detecting proteins because their large volumes hinder the approach to nanogaps. In previous work, we achieved ultra-sensitive protein detection by applying hydrogels as SERS substrates with a triangular gold nanoplates (AuNTs) array via a well-designed Gel Filter Trapping (GFT) method for introducing proteins into nanogaps. However, the cost of time before detection limited them to practical applications, such as point-of-care testing. In this study, we utilized a xerogel that rapidly absorbs water and concomitantly shrinks, enabling rapid one-step protein detection by SERS.