Presentation Information
[17a-S4_201-6]Glass Nanopipette Engineering and Its Applications for Metrologobiology
〇(PC)Linhao Sun1, Han Gia Nguyen1, Shinji Watanabe1 (1.Kanazawa Univ)
Keywords:
Nanopipette,Pore Geometry,Metrologobiology
Nanopipettes are routinely fabricated by a two-step process—thermal melting followed by mechanical pulling—to produce microscale-to-nanoscale pores. These probes enable a wide range of applications including topographic imaging [1], molecular delivery and trapping [2], biochemical sensing [3], and materials engineering [4]. However, widespread adoption — particularly in materials science, electrochemistry, biophysics and biochemistry — has been limited by poor control over pore sizes, which reduces reproducibility across experiments. Besides, in numerous modeling, nanopipette accurate geometrical characterization still remains a key challenge. Addressing these limitations requires integrated advances in fabrication, non-destructive geometrical characterization (Fig. 1), and precise pore-size controlling (shown in presentation).
In this presentation, I will summarize our recent progress [5–6] in three aspects: (i) nanopipette fabrication and the key geometrical parameters governing performance (inner/outer pore diameter, half-cone angle); (ii) non-destructive geometrical characterization using transmission electron microscopy; and (iii) nanometer-resolution pore-size control enabled by atomic layer deposition method. Finally, I will highlight our recent applications of nanopipettes in biological imaging [7], sensing [8], and materials engineering [4].
In this presentation, I will summarize our recent progress [5–6] in three aspects: (i) nanopipette fabrication and the key geometrical parameters governing performance (inner/outer pore diameter, half-cone angle); (ii) non-destructive geometrical characterization using transmission electron microscopy; and (iii) nanometer-resolution pore-size control enabled by atomic layer deposition method. Finally, I will highlight our recent applications of nanopipettes in biological imaging [7], sensing [8], and materials engineering [4].