The 74th Annual Meeting of the Japan Society for Cell Biology
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Session Details

Oral PresentationSymposium

[Japanese session]Understanding and medical application of proteostasis-From proteostasis to organelle homeostasis-

Wed. Jun 29, 2022 1:45 PM - 4:15 PM JST
Wed. Jun 29, 2022 4:45 AM - 7:15 AM UTC
Venue B Heian
Organizer: Kazuhiro Nagata (Japan Agency for Medical Research and Development)
This R&D area aims to clarify the relationship between structure and function of proteins based on evidence obtained from biochemical and structural biological approaches, to understand the molecular pathways that cause various diseases, and to discover potential solutions for healthcare or methods to maintain good health. This symposium introduces the R&D Projects focusing on molecular mechanism from proteostasis to organelle homeostasis and the relationship with diseases.
1:45 PM - 1:50 PM JST(4:45 AM - 4:50 AM UTC)

[2B-108]opening remarks

*Kazuhiro Nagata1 (1. JT Biohistory Research Hall)
1:50 PM - 2:15 PM JST(4:50 AM - 5:15 AM UTC)

[2B-109]Proteostasis in the ER: Significance of reductive reactions in an oxidative environment

*Kazuhiro Nagata1,2, Kaiku Uegaki2, Chika Tsutsumi2, Ryo Ushioda2 (1. JT Biohistory Research Hall, 2. Department of life Sciences, Kyoto Sangyo University)
2:15 PM - 2:40 PM JST(5:15 AM - 5:40 AM UTC)

[2B-110]Constitutive Activation of XBP1 but not ATF6 Significantly Rescues Defects in Medaka Heart Induced by ER Stress Lasting from Fertilization

*Kazutoshi Mori1 (1. Graduate School of Science, Kyoto University)
2:40 PM - 3:05 PM JST(5:40 AM - 6:05 AM UTC)

[2B-111]Analysis of hidden ORFs

*Akinobu Matsumoto1 (1. Medical Institute of Bioregulation, Kyushu University)
3:05 PM - 3:20 PM JST(6:05 AM - 6:20 AM UTC)

[2B-112]Hikeshi-mediated nuclear import of molecular chaperone HSP70: functions in regulation of HSF1 transcription activity and nuclear proteostasis

*Shingo Kose1, Ai Watanabe1, Naoko Imamoto1 (1. Cellular Dynamics Lab. RIKEN CPR)
3:20 PM - 3:45 PM JST(6:20 AM - 6:45 AM UTC)

[2B-113]Deciphering proteostasis regulation mechanism through understanding of disaggregation process for amyloid fibrils

*Motomasa Tanaka1, yoshiko Nakagawa1, Yusuke Komi1 (1. RIKEN Center for Brain Science)
3:45 PM - 4:10 PM JST(6:45 AM - 7:10 AM UTC)

[2B-114]Ribosome-associated quality control and organelle homeostasis

*Toshiaki Izawa1, Teruhiko Suzuki1, Toshifumi Inada2,1 (1. Graduate School of Pharmaceutical Sciences, Tohoku University, 2. The Institute of Medical Science, The University of Tokyo)
4:10 PM - 4:15 PM JST(7:10 AM - 7:15 AM UTC)

[2B-115]closing remarks

*Tamao Endo1 (1. Tokyo Metropolitan Institute of Gerontology)
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