Oral Presentation10 Transcriptional regulation & Epigenetics

1:15 PM - 1:30 PM JST(4:15 AM - 4:30 AM UTC)

[OP10e-3] Single-Cell CRISPR Activation Screen in Primary Embryonic Hepatocytes Identifies Potent Transcriptional Regulators for Metabolic Gene Activation and Embryonic Gene Suppression during Maturationシングルセル解析をリードアウトとしたCRISPR Activationスクリーニングによる、胎児肝細胞の成熟分化における代謝関連分子の活性化および胎児型遺伝子の抑制を担う転写制御因子の同定

*Atsuhiro Taguchi¹, Alexandre Magalhães¹, Helene Kretzmer¹, Denes Hnisz¹, Lars Wittler¹, Alexander Meissner¹ (1. Max Planck Institute for Molecular Genetics)

Keywords:

organoid,maturation,hepatocyte,CRISPR activation,single cell

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