Session Details
Symposium 05 : Direct reprogramming from somatic cells to desired cells by pioneer transcription factors (in English)
Tue. Jul 25, 2023 12:45 PM - 2:45 PM JST
Tue. Jul 25, 2023 3:45 AM - 5:45 AM UTC
Tue. Jul 25, 2023 3:45 AM - 5:45 AM UTC
Room C 3F Shirakashi
Chairperson:Yuuri Yasuoka(RIKEN IMS)
Recent advances in omics analysis have revealed various cell differentiation lineages and the genes involved in them. Accordingly, "direct reprogramming," a technology that directly differentiates somatic cells such as fibroblasts into desired cells without the need for stem cells, has emerged as a next-generation regenerative medicine. In this symposium, we invite speakers to present their latest results related to the development of direct reprogramming methods focusing on pioneer transcription factor functions and distinctive omics technologies. Presenting a reliable path from the understanding of gene regulatory mechanisms to regenerative medicine, we would like to illuminate a next direction of developmental biology as pioneers of this field.
[S05-1]Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
*Makiko Iwafuchi1,2, Satoshi Matsui1, Marissa Granitto1, Gerardo Mirizio1,2, Samuel Sampson1,2, Hee-Woong Lim1,2 (1. Cincinnati Children's Hospital Medical Center, 2. University of Cincinnati College of Medicine)
[S05-2]Network Analysis and Modeling Reveals Cell Fate Transition Mechanism in Direct Lineage Reprogrammingネットワーク解析とモデリングによるダイレクトリプログラミングの解析
*Kenji Kamimoto1 (1. Washington University Medical School in St.Louis)
[S05-3]Photo-isolation chemistry for high-resolution and deep spatial transcriptome with tissue sections光単離化学(PIC)による高解像度かつ高深度の空間オミクス解析
*Shinya Oki1 (1. Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine)
[S05-4]Massively parallel dissection of regulatory code underlying neural differentiation大規模並列機能解析による神経分化制御コードの解読
*Fumitaka Inoue1 (1. ASHBi, Kyoto Univ.)