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[O6-2]Dissecting cross-population polygenic heterogeneity of multimorbidity across respiratory and cardiometabolic diseases

Yuji Yamamoto1, Yuya Shirai1,2, Kyuto Sonehara1,3,4, Shinichi Namba1,3,4, Kenichi Yamamoto1,5, Ryuya Edahiro1,2,4, Ken Suzuki1,6, Takafumi Ojima1,3,4,7, Yoshito Takeda2, Koichi Matsuda8, Atsushi Kumanogoh2,9,10,11,12,13, Toshimasa Yamauchi6,14, Kadowaki Takashi6,15, Yukinori Okada1,3,4,16,17 (1.Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan, 2.Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan, 3.Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4.Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 5.Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan, 6.Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 7.Graduate School of Medicine, Tohoku University, Sendai, Japan, 8.Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan, 9.Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan, 10.Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Japan, 11.Center for Infectious Diseases for Education and Research (CiDER), Osaka University, Suita, Japan, 12.Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED CREST), Osaka University, Suita, Japan, 13.Center for Advanced Modalities and DDS (CAMaD), Osaka University, Suita, Japan, 14.AMED CREST, Japan Agency for Medical Research and Development, Tokyo, Japan, 15.Toranomon Hospital, Tokyo, Japan, 16.Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan, 17.Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan)

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