Session Details

[O6]Oral Session 6 Bioinformatics, Statistical Genetics, Database/Biobank, Functional Genomics

Thu. Oct 10, 2024 12:55 PM - 1:45 PM JST
Thu. Oct 10, 2024 3:55 AM - 4:45 AM UTC
Room 6(Castle, 1F)
Chairs:Hidehito Inagaki(Fujita Health University), Natsuhiko Kumasaka(The Institute of Medical Science, The University of Tokyo)

[O6-1]LPA, KIV2, serum Lp(a), and the lifetime risk of Cancers and Cardiovascular diseases

Noriko Tanaka1,2,3, Hidemasa Nose4, Ayano Takeuchi4, Makiko Mieno5, Tomio Arai6 (1.Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan, 2.Genome Medical Science Project-Toyama, National Center for Global Health and Medicine, Tokyo, Japan, 3.Clinical Research Center, Fukushima Medical University, Fukushima, Japan, 4.Department of integrated Science and Engineering for Sustainable Societies, Chuo University, Tokyo, Japan, 5.Department of Medical Informatics, Center for Information, Jichi Medical University, Tochigi, Japan, 6.Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan,)

[O6-2]Dissecting cross-population polygenic heterogeneity of multimorbidity across respiratory and cardiometabolic diseases

Yuji Yamamoto1, Yuya Shirai1,2, Kyuto Sonehara1,3,4, Shinichi Namba1,3,4, Kenichi Yamamoto1,5, Ryuya Edahiro1,2,4, Ken Suzuki1,6, Takafumi Ojima1,3,4,7, Yoshito Takeda2, Koichi Matsuda8, Atsushi Kumanogoh2,9,10,11,12,13, Toshimasa Yamauchi6,14, Kadowaki Takashi6,15, Yukinori Okada1,3,4,16,17 (1.Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan, 2.Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan, 3.Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4.Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 5.Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan, 6.Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 7.Graduate School of Medicine, Tohoku University, Sendai, Japan, 8.Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan, 9.Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan, 10.Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Japan, 11.Center for Infectious Diseases for Education and Research (CiDER), Osaka University, Suita, Japan, 12.Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED CREST), Osaka University, Suita, Japan, 13.Center for Advanced Modalities and DDS (CAMaD), Osaka University, Suita, Japan, 14.AMED CREST, Japan Agency for Medical Research and Development, Tokyo, Japan, 15.Toranomon Hospital, Tokyo, Japan, 16.Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan, 17.Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan)

[O6-3]Genetic determinants of centenarian longevity are associated with multiple age-related diseases and a longer healthspan

Takashi Sasaki1, Shu Tadaka2, Takumi Hirata3, Yoshinori Nishimoto4, Ryo Shikimoto1, Yukiko Abe1, Aiko Shiohama1, Matsuyuki Shirota2,5,6,7, Ikuko Motoike2,6, Gen Tamiya2,5,7,8, Kengo Kinoshita2,6,7,9, Masayuki Yamamoto2,7, Latysheva Natasha S10, Joseph R Ledsam11, Hiroki Kayama11, Toru Takebayashi12, Hideyuki Okano13, Makoto Suematsu14,15, Kenjiro Kosaki16, Nobuyoshi Hirose17, Yasumichi Arai1,18 (1.Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan, 2.Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan, 3.Human Care Research Team, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan, 4.Department of Neurology, Keio University School of Medicine, Tokyo, Japan, 5.Graduate School of Medicine, Tohoku University, Miyagi, Japan, 6.Graduate School of Information Sciences, Tohoku University, Miyagi, Japan, 7.Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Miyagi, Japan, 8.RIKEN Center for Advanced Intelligence Project, Tokyo, Japan, 9.Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan, 10.Google DeepMind, London, UK, 11.Google Japan G.K., Tokyo, Japan, 12.Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan, 13.Department of Physiology, Keio University School of Medicine, Tokyo, Japan, 14.Central Institute for Experimental Medicine and Life Science, Kanagawa, Japan, 15.WPI-Bio2Q Research Institute, Keio University, Tokyo, Japan, 16.Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan, 17.Houtokukai Utsunomiya Hospital, Tochigi, Japan, 18.Faculty of Nursing and Medical Care, Keio University, Tokyo, Japan)

[O6-4]The NBDC-DDBJ imputation server and controlled access reference panel datasets in Japan

Tsuyoshi Hachiya1, Manabu Ishii1, Kozo Nishida1, Yosuke Kawai2, Seik-Soon Khor2,3, Minae Kawashima4, Nobutaka Mitsuhashi4, Asami Fukuda5, Yuichi Kodama5, Takatomo Fujisawa5, Katsushi Tokunaga2, Toshihisa Takagi6 (1.Genome Analytics Japan Inc., Tokyo, Japan, 2.Genome Medical Science Project, National Center for Global Health and Medicine, Tokyo, Japan, 3.Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 4.Database Center for Life cience, Research Organization of Information and System, Chiba, Japan, 5.Bioinformation and DDBJ Center, National Institute of Genetics, Shizuoka, Japan, 6.Toyama University of International Studies, Toyama, Japan)

[O6-5]Functional analysis of seven rare DPYD variants associated with 5FU-based anticancer drug toxicity in cancer patients

Yuta Sudo1, Yoko Nakajima1, Yasuaki Yasuda1, Katsuyuki Yokoi1, Yasuko Shinkai2, Yasuhiro Maeda3, Tetsushi Yoshikawa1, Tetsuya Ito1, Hiroki Kurahashi2 (1.Department of Pediatrics, Fujita Health University School of Medicine, 2.Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 3.Open Facility Centers, Fujita Health University)