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[O6-3]Genetic determinants of centenarian longevity are associated with multiple age-related diseases and a longer healthspan

Takashi Sasaki1, Shu Tadaka2, Takumi Hirata3, Yoshinori Nishimoto4, Ryo Shikimoto1, Yukiko Abe1, Aiko Shiohama1, Matsuyuki Shirota2,5,6,7, Ikuko Motoike2,6, Gen Tamiya2,5,7,8, Kengo Kinoshita2,6,7,9, Masayuki Yamamoto2,7, Latysheva Natasha S10, Joseph R Ledsam11, Hiroki Kayama11, Toru Takebayashi12, Hideyuki Okano13, Makoto Suematsu14,15, Kenjiro Kosaki16, Nobuyoshi Hirose17, Yasumichi Arai1,18 (1.Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan, 2.Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan, 3.Human Care Research Team, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan, 4.Department of Neurology, Keio University School of Medicine, Tokyo, Japan, 5.Graduate School of Medicine, Tohoku University, Miyagi, Japan, 6.Graduate School of Information Sciences, Tohoku University, Miyagi, Japan, 7.Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Miyagi, Japan, 8.RIKEN Center for Advanced Intelligence Project, Tokyo, Japan, 9.Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan, 10.Google DeepMind, London, UK, 11.Google Japan G.K., Tokyo, Japan, 12.Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan, 13.Department of Physiology, Keio University School of Medicine, Tokyo, Japan, 14.Central Institute for Experimental Medicine and Life Science, Kanagawa, Japan, 15.WPI-Bio2Q Research Institute, Keio University, Tokyo, Japan, 16.Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan, 17.Houtokukai Utsunomiya Hospital, Tochigi, Japan, 18.Faculty of Nursing and Medical Care, Keio University, Tokyo, Japan)

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