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DNA methylation alterations in F1 sperm by gestational arsenic exposure of F0 mice and their inheritance in both parent genomes of F2 embryos after epigenetic reprogramming

Germline emerges as primordial germ cells during embryogenesis and is maintained for a long period of time to maintain the reproductive function. The nutritional condition derived from mother during embryogenesis and neonatal development, and from the surrounding environment during adulthood, influences the metabolic state of germ cells and supporting cells, and is Involved in the control of epigenomic state and reproductive function. However, the research to elucidate such mechanisms is only just beginning. In this project, we will discuss the progress and perspectives of this field of research, which we define as "Reprometabolism".<br>

【J】Reprometabolism: Nutritional and metabolic control of the reproductive cycle

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[1MS-07-06]DNA methylation alterations in F1 sperm by gestational arsenic exposure of F0 mice and their inheritance in both parent genomes of F2 embryos after epigenetic reprogramming

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