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Development of the amido-bridged nucleic acid-modified antisense oligonucleotide targeting MCM8 as a cancer-specific chemosensitizer for platinum compounds

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Sponsored by: AMED: Japan Agency for Medical Research and Development, Genome-Based Drug Discovery Research for N-of-1+ Patients

In this symposium, we will discuss innovative approaches to disease treatment through artificial interventions in molecular mechanisms associated with genome, such as nucleic acid metabolism, DNA repair, transcription, and protein synthesis. Currently, there are high expectations for the practical applications of gene editing techniques and the control of gene expression using artificial nucleic acids. We will introduce cutting-edge researches that enable the development of new technologies from unique perspectives. Based on these studies, we aim to develop new treatments for intractable diseases, such as cancer and genetic disorders.<br>

The 47th Annual Meeting of the Molecular Biology Society of Japan

Presentation Information

[1PS-06-04(1P-858)]Development of the amido-bridged nucleic acid-modified antisense oligonucleotide targeting MCM8 as a cancer-specific chemosensitizer for platinum compounds

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