The 47th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Open-call Symposium : [1PS-06] The Cutting Edge in Genome Metabolism Research: Advancing Disease Treatment

[1PS-06]【J】The Cutting Edge in Genome Metabolism Research: Advancing Disease Treatment

Wed. Nov 27, 2024 4:45 PM - 7:00 PM JST
Wed. Nov 27, 2024 7:45 AM - 10:00 AM UTC
Room 6(Fukuoka International Congress Center, 4F 411+412)
Organizer: Tomoo Ogi (Nagoya University), Shinichiro Nakada (Osaka University)
Sponsored by: AMED: Japan Agency for Medical Research and Development, Genome-Based Drug Discovery Research for N-of-1+ Patients
In this symposium, we will discuss innovative approaches to disease treatment through artificial interventions in molecular mechanisms associated with genome, such as nucleic acid metabolism, DNA repair, transcription, and protein synthesis. Currently, there are high expectations for the practical applications of gene editing techniques and the control of gene expression using artificial nucleic acids. We will introduce cutting-edge researches that enable the development of new technologies from unique perspectives. Based on these studies, we aim to develop new treatments for intractable diseases, such as cancer and genetic disorders.
4:45 PM - 4:50 PM JST(7:45 AM - 7:50 AM UTC)

Introduction

4:50 PM - 5:07 PM JST(7:50 AM - 8:07 AM UTC)

[1PS-06-01]Genome alterations and genome editing induced by multiple DNA nicks

○Shinichiro Nakada1,2, Akiko Tomita1,2 (1. Kyoto Pre. Univ. Med., 2. Osaka Univ)
Comment()
5:07 PM - 5:24 PM JST(8:07 AM - 8:24 AM UTC)

[1PS-06-02(1P-078)]Repair of topoisomerase 1–induced DNA damage by TDP2

○Masataka Tsuda1,2, Naoto Shimizu1,2, Yusaku Hamada1,2, Kazuki Izawa1 (1. National Institute of Health Sciences, 2. Hiroshima University)
Comment()
5:24 PM - 5:41 PM JST(8:24 AM - 8:41 AM UTC)

[1PS-06-03]Regulation of cGAS-STING activation by the immune checkpoint molecule PD-L1

○Naoe Nihira1, Tomohiko Ohta1 (1. St. Marianna University Graduate School of Medicine)
Comment()
5:41 PM - 5:58 PM JST(8:41 AM - 8:58 AM UTC)

[1PS-06-04(1P-858)]Development of the amido-bridged nucleic acid-modified antisense oligonucleotide targeting MCM8 as a cancer-specific chemosensitizer for platinum compounds

○Yuki Uchibori1, Masaki Suekuni1, Yuko Kokaji1, Kazumasa Yoshida1, Yuuya Kasahara2,3, Masatoshi Fujita1 (1. Grad. Sch. Pharm. Sci., Kyushu Univ., 2. NIBIOHN., 3. Grad. Sch. Pharm. Sci., Osaka Univ.)
Comment()
5:58 PM - 6:15 PM JST(8:58 AM - 9:15 AM UTC)

[1PS-06-05(1P-352)]Artificial regulation of gene expression by triplex nucleic acid and triplex nucleic acid-binding proteins

○Hidetaka Torigoe1, Ryo Shinoda1, Maiko Shimmura,1, Kazuki Kiuchi1, Norihiro Sato1, Takuma Katayama1 (1. Tokyo University of Science)
Comment()
6:15 PM - 6:32 PM JST(9:15 AM - 9:32 AM UTC)

[1PS-06-06]Development of ASO therapeutics for rare genome instability disorders

○Yuka Nakazawa1, Lin Ye1, Taichi Oso1, Chikako Senju1, Kana Kato1, Mayuko Shimada1, Tomoo Ogi1 (1. Nagoya University)
Comment()
6:32 PM - 6:49 PM JST(9:32 AM - 9:49 AM UTC)

[1PS-06-07]TBA

○Tojo Nakayama1 (1. NucleoTIDE and PepTIDE Drug Discovery Center, Institute of Science Tokyo)
Comment()
6:49 PM - 7:00 PM JST(9:49 AM - 10:00 AM UTC)

General Discussion

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