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Analysis on inhibitory mechanism of RNA-binding allosteric effect on repression of phase separation and precipitation

Recently, Neurodegenerative diseases like ALS via precipitation (PPT) of RNA-binding proteins (RBPs) in neuron have been focused. The RBP PPT mediates its phase separation (PS). RNA prevents RBP from PS, showing that RNA is a possible seed for an ALS drug. View points of basic and also clinical aspects are essential for analysis on ALS because of its divergency. Our session has diverse topics and will present a novel mechanism of the disease onset.<br>

【J】Neurodegenerative disease and its onset mechanism via RNA-binding proteins-Molecular pathology and therapeutics against incurable neurodegenerative disease like amyotrophic lateral sclerosis (ALS)-

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[2PS-05-01]Analysis on inhibitory mechanism of RNA-binding allosteric effect on repression of phase separation and precipitation

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