The 47th Annual Meeting of the Molecular Biology Society of Japan
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Open-call Symposium : [2PS-05] Neurodegenerative disease and its onset mechanism via RNA-binding proteins-Molecular pathology and therapeutics against incurable neurodegenerative disease like amyotrophic lateral sclerosis (ALS)-

[2PS-05]【J】Neurodegenerative disease and its onset mechanism via RNA-binding proteins-Molecular pathology and therapeutics against incurable neurodegenerative disease like amyotrophic lateral sclerosis (ALS)-

Thu. Nov 28, 2024 4:45 PM - 7:00 PM JST
Thu. Nov 28, 2024 7:45 AM - 10:00 AM UTC
Room 5(Fukuoka International Congress Center, 4F 409+410)
Organizer: Riki Kurokawa (Saitama Medcal University), Masato Katahira (Kyoto University)
Recently, Neurodegenerative diseases like ALS via precipitation (PPT) of RNA-binding proteins (RBPs) in neuron have been focused. The RBP PPT mediates its phase separation (PS). RNA prevents RBP from PS, showing that RNA is a possible seed for an ALS drug. View points of basic and also clinical aspects are essential for analysis on ALS because of its divergency. Our session has diverse topics and will present a novel mechanism of the disease onset.
4:45 PM - 4:48 PM JST(7:45 AM - 7:48 AM UTC)

Introduction

4:48 PM - 5:02 PM JST(7:48 AM - 8:02 AM UTC)

[2PS-05-01]Analysis on inhibitory mechanism of RNA-binding allosteric effect on repression of phase separation and precipitation

○Riki Kurokawa1 (1. Saitama Medical University)
Comment()
5:02 PM - 5:16 PM JST(8:02 AM - 8:16 AM UTC)

[2PS-05-02]Functional Properties of RNA Binding Proteins in the Pathogenesis of ALS/FTLD and Development of Therapeutic Strategies Based on It

○Shinsuke Ishigaki1 (1. Shiga University of Medical Science)
Comment()
5:16 PM - 5:30 PM JST(8:16 AM - 8:30 AM UTC)

[2PS-05-03]Therapeutic Strategy for Amyotrophic Lateral Sclerosis Targeting TARDBP Exitron Splicing

○Akihiro Sugai1 (1. Niigata University)
Comment()
5:30 PM - 5:44 PM JST(8:30 AM - 8:44 AM UTC)

[2PS-05-04]Loss-of-function of nuclear TDP-43 and regulation of UNC13A splicing in ALS/FTD

○Yuka Mitsuhashi Koike1 (1. Brain Research Institute, Niigata University)
Comment()
5:44 PM - 5:54 PM JST(8:44 AM - 8:54 AM UTC)

[2PS-05-05(2P-159)]Isotope effect on protein-RNA interactions as a risk factor for ALS

○Akira Ishiguro1, Minoru Sakama2, Takuya Saze3, Masaki Kawaguchi2, Kei-ichi Katayama4, Yoshiaki Nakayama4 (1. Hosei Univ., 2. Tokushima Univ., 3. NIFS, 4. Wakayama-Med Univ.)
Comment()
5:54 PM - 6:04 PM JST(8:54 AM - 9:04 AM UTC)

[2PS-05-06(2P-357)]From Systematic Identification of Human Non-Membranous Structures to Understanding Neurodegenerative Disease

○shin Kobayashi1, Yoshifumi Kawamura2, Eriko Fukuda1, Nami Sugita3, Naoki Goshima4, Shungo Adachi 5 (1. National Institute of Advanced Industrial Science and Technology , 2. Fukushima Translational research Foundation, 3. Japan Biological Informatics Consortium, 4. Musashino University, 5. National Cancer Center Research Institute)
Comment()
6:04 PM - 6:14 PM JST(9:04 AM - 9:14 AM UTC)

[2PS-05-07(2P-192)]Molecular mechanism of NOP56 GGCCUG Repeat Associated Non-AUG (RAN) translation

○Mayuka Hasumi1, Hayato Ito1, Kodai Machida2, Tatsuya Niwa1,3, Tomoya Taminato4, Yoshitaka Nagai4, Hiroaki Imataka2, Hideki Taguchi1,3 (1. Science Tokyo, Sch. Life Sci. Tech., , 2. Univ. of Hyogo, Dept. of Eng., 3. Science Tokyo, IIR, 4. Kindai univ., Med.)
Comment()
6:14 PM - 6:28 PM JST(9:14 AM - 9:28 AM UTC)

[2PS-05-08]Dysregulation of lysosomal trafficking in neurodegenerative diseases

○Yukiko Sasazawa1,2, Shinji Saiki2,3, Nobutaka Hattori2 (1. Res. Inst. Dis. of Old Age, Fac. of Med., Juntendo Univ. , 2. Dept. of Neurol., Fac. of Med., Juntendo Univ. , 3. Dept. of Neurol., Inst. of Med., Univ of Tsukuba)
Comment()
6:28 PM - 6:42 PM JST(9:28 AM - 9:42 AM UTC)

[2PS-05-09]Analysis and regulation of nucleic acid structures involved in neurodegenerative diseases depending on the surrounding environments

○Hisae Tateishi-Karimata Tateishi-Karimata1,2, Naoki Sugimoto2 (1. FIRST, Konan University, 2. FIBER, Konan University)
Comment()
6:42 PM - 6:56 PM JST(9:42 AM - 9:56 AM UTC)

[2PS-05-10]Interaction of RNA/DNA aptamers with causative proteins of neurodegenerative diseases and inactivation mechanisms

○Masato Katahira1 (1. Kyoto University)
Comment()
6:56 PM - 7:00 PM JST(9:56 AM - 10:00 AM UTC)

Conclusion

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