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Regulation of the PI3K/AKT/PTEN cascade by oncogenic miR-17~92 and mRNA alternative polyadenylation

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Protein synthesis (mRNA translation) represents the most energy-consuming process in the cells. Alterations in mRNA translation and energy metabolism play a central role in homeostatic adaptation to stress, and when dysregulated, result in a variety of human pathologies, including cancer and metabolic diseases. Nevertheless, due to the historical and technological limitations, the relationship between mRNA translation and energy metabolism has remained largely underexplored. In this session, we will focus on emerging data that delineate the mechanisms orchestrating translational and metabolic programs under physiological and pathological conditions. Additionally, we will discuss the implications of these findings in opening potential therapeutic avenues to improve the treatment of human diseases.<br>

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[3AS-11-09]Regulation of the PI3K/AKT/PTEN cascade by oncogenic miR-17~92 and mRNA alternative polyadenylation

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