Session Details

[3AS-11]【E】Cross-talk between mRNA translation and metabolic programs in homeostasis and diseases

Fri. Nov 29, 2024 9:00 AM - 11:15 AM JST
Fri. Nov 29, 2024 12:00 AM - 2:15 AM UTC
Room 11(Fukuoka International Congress Center, 2F 202)
Organizer: Masahiro Morita (University of Texas Health Science Center at San Antonio), Ivan Topisirovic (McGill University)
Protein synthesis (mRNA translation) represents the most energy-consuming process in the cells. Alterations in mRNA translation and energy metabolism play a central role in homeostatic adaptation to stress, and when dysregulated, result in a variety of human pathologies, including cancer and metabolic diseases. Nevertheless, due to the historical and technological limitations, the relationship between mRNA translation and energy metabolism has remained largely underexplored. In this session, we will focus on emerging data that delineate the mechanisms orchestrating translational and metabolic programs under physiological and pathological conditions. Additionally, we will discuss the implications of these findings in opening potential therapeutic avenues to improve the treatment of human diseases.

Introduction

[3AS-11-01]Investigation of mRNA surveillance and translation-associated RNA-helicase in Plasmodium falciparum

○Slavica Pavlovic Djuranovic1, Elisha Mugo1, Jessey Erath1, Lena Street2, Marko Jovanovic2, Sergej Djuranovic1, Slavica Pavlovic Djuranovic1 (1. Washington University School of Medicine in Saint Louis, 2. Columbia University, New York)
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[3AS-11-02]Regulation of systemic energy metabolism through mRNA degradation of secretory proteins

○Sakie Katsumura1,2, Masahiro Morita1,2 (1. Univ. of Texas Health San Antonio, 2. Osaka Univ.)
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[3AS-11-03]polyA track associated frameshifting in control of environmental stress survival and development

Geralle Powell1, Mujeeb Pirzada1, Courtney F Jungers1, Amber Stratman1, ○Sergej Djuranovic1 (1. Washington University School of Medicine, Department of Cell Biology and Physiology)
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[3AS-11-04]Local translation atlas revealed by APEX-Ribo-Seq

○Shintaro Iwasaki1,2 (1. RIKEN Cluster for Pioneering Research, 2. Dep. Comp. Biol. and Med. Sci., Grad. Sch. Front. Sci., Univ. Tokyo)
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[3AS-11-05(3P-857)]Inhibition of ribosome biogenesis in cancer

Rita Ferreira2, Kate Hannan2, Konstantin Panov3, Thejanni Udumanne2, Amee George2, Adria Closa2, Zaka Yuen2, Eduardo Eyras2, Perlita Poh2, Kylee MacLachlan2, Mitchell Dwyer2, Eric Kusnadi1, Richard Rebello1, Alisee Huglo1, Shelley Hedwards1, Mitchell Lawrence1, Gail Risbridger1, Renea Taylor1, Ashlee Clark4, Sharon Pok2, Narci Treon2, Mustapha Haddach5, Denis Drygin5, Ross Hannan2, Nadine Hein2, ○Luc Furic1 (1. Peter Maccallum Cancer Centre, 2. Australian National University, 3. Queen's University Belfast, 4. Monash University, 5. Pimera Inc)
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[3AS-11-06]Reprogrammed mRNA processing, translation and metabolism underpins therapy-induced plasticity and resistance in melanoma

Arwa Alkaraki1,2, Tiffany Parmenter1, Eric Kusnadi1,2, Michael Lee1,2, Julie Lorent3, David Papadopoli4,5, Margarete Kleinschmidt1, Jian Kang1, Anna Trigos1,2, Teresa Ward1, Karen Sheppard1,2, Kaylene Simpson1,2, Richard Pearson1,2, Ola Larsson3, Ivan Topisirovic4,5, Vihandha Wickramasinghe1,2, Grant McArthur1,2, ○Lorey Smith1,2 (1. Peter MacCallum Cancer Centre, 2. University of Melbourne, 3. Karolinska Institute, 4. Lady Davis Institute, 5. McGill University)
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[3AS-11-07]Targeting resistance to cancer therapy through translational control of metabolism

○Laura Hulea1,2, Alejandro Schcolnik-Cabrera1,2, Victor Gife1,2, Anavasadat Sadr Hashemi Nejad1,2, Meriem Takdenti1,2, Zaynab Nouhi2, Katie Fooks3,4, Martin Roffe5, Tommy Alain5, Ivan Topisirovic3,4, Jerry Pelletier3, Raquel Aloyz3,4, François Mercier3,4 (1. University of Montreal, 2. Maisonneuve-Rosemont Hospital Research Center, Montreal, Canada , 3. McGill University, 4. Lady Davis Institute for Medical Research, Montreal, Canada , 5. University of Ottawa)
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[3AS-11-08]Epigenetic coordination of transcription and mRNA translation coordinate hypoxia-associated cellular plasticity

Kathleen Watt2, Bianca Dauber1, Ivan Topisirovic3, Ola Larsson2, ○Lynne-Marie Postovit1 (1. Queen's University, 2. Karolinska Institute, 3. McGill University)
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[3AS-11-09]Regulation of the PI3K/AKT/PTEN cascade by oncogenic miR-17~92 and mRNA alternative polyadenylation

○Thomas F Duchaine1 (1. Department of Biochemistry & Goodman Cancer Institute, McGill University)
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[3AS-11-10]Insulin Receptor Regulates Bioenergetics to Govern Tumor Initiation

○Vuk Stambolic1,2,3 (1. Princess Margaret Cancer Centre/University Health Network, 2. University of Toronto, 3. Toronto, ON, Canada)
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