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Determinants of efficient replication origins in vertebrates and their interaction with transcription

Genomic DNA is folded into multiple layers in the cell nucleus. Megabase-sized chromatin domains are formed, and genes that are distant from each other on the linear genome are sometimes close together in the three-dimensional (3D) nuclear space. This higher-order structure changes dynamically during development and differentiation, regulating DNA replication and transcription, and its abnormalities lead to diseases. In this symposium, we invite researchers who are taking on the challenge to elucidate the genome dynamics from the standpoint of genome replication to the 3D genome organization using advanced technologies, including single-cell genomics and Hi-C, and discuss the latest findings.<br>

【E】Mechanisms, dynamics, and functions of the 3D genome organization

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[3AS-12-06]Determinants of efficient replication origins in vertebrates and their interaction with transcription

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