The 47th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Open-call Symposium : [3AS-12] Mechanisms, dynamics, and functions of the 3D genome organization

[3AS-12]【E】Mechanisms, dynamics, and functions of the 3D genome organization

Fri. Nov 29, 2024 9:00 AM - 11:15 AM JST
Fri. Nov 29, 2024 12:00 AM - 2:15 AM UTC
Room 12(Fukuoka International Congress Center, 2F 203)
Organizer: Ichiro Hiratani (RIKEN), Noriko Saitoh (The Cancer Institute of JFCR)
Genomic DNA is folded into multiple layers in the cell nucleus. Megabase-sized chromatin domains are formed, and genes that are distant from each other on the linear genome are sometimes close together in the three-dimensional (3D) nuclear space. This higher-order structure changes dynamically during development and differentiation, regulating DNA replication and transcription, and its abnormalities lead to diseases. In this symposium, we invite researchers who are taking on the challenge to elucidate the genome dynamics from the standpoint of genome replication to the 3D genome organization using advanced technologies, including single-cell genomics and Hi-C, and discuss the latest findings.
9:00 AM - 9:02 AM JST(12:00 AM - 12:02 AM UTC)

Introduction

9:02 AM - 9:19 AM JST(12:02 AM - 12:19 AM UTC)

[3AS-12-01]Nuclear long non-coding RNAs contributing to super-enhancer and 3D genome structure in breast cancer dormancy

○Noriko Saitoh1, Maierdan Palihati1, Yuichi Ichikawa1, Hiroaki Tachiwana1 (1. The Cancer Institute of JFCR)
Comment()
9:19 AM - 9:42 AM JST(12:19 AM - 12:42 AM UTC)

[3AS-12-02]A new group of long intronic RNAs shapes genome architecture of neurons by bridging long with short neuronal genes.

Wenjing Kang1,2, Andrea Abou Yaghi1,2, Quentin Verron1,2, Wing Hin Yip1,2,3, Xiaoze Li Wang1,2, Masaki Kato4, Hazuki Takahashi4, Chi Wai Yip4, Takeya Kasukawa4, Rodrigo Pracana3, Nicola Crosetto1,2,3, Piero Carninci4,3, ○Marzena Magda Bienko1,2,3 (1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, 2. Science for Life Laboratory, Stockholm, Sweden, 3. Human Technopole, Milan, Italy, 4. RIKEN Center for Integrative Medical Sciences, Yokohama, Japan)
Comment()
9:42 AM - 9:59 AM JST(12:42 AM - 12:59 AM UTC)

[3AS-12-03]Context-specific roles of cohesin for higher-order chromatin folding and transcription

○Ryuichiro Nakato1 (1. The University of Tokyo)
Comment()
9:59 AM - 10:16 AM JST(12:59 AM - 1:16 AM UTC)

[3AS-12-04(3P-099)]The functional role of histone H3K4me1 in chromatin contacts and gene activation during embryonic stem cell differentiation

○Naoki Kubo1,2, Hiroyuki Sasaki3, Bing Ren4 (1. RIKEN BRC, 2. Research Institute for Microbial Diseases, Osaka University, 3. Kyushu University, 4. UC San Diego)
Comment()
10:16 AM - 10:33 AM JST(1:16 AM - 1:33 AM UTC)

[3AS-12-05(3P-059)]Cell growth-coordinated regulation of the function of the DNA bending factor IHF for ensuring timely replication initiation

○Kazutoshi Kasho1, Mizuki Yoshida1, Rion Satomura1, Kenya Miyoshi1, Wataru Nakagaki1, Sho Nakazono1, Tsutomu Katayama1 (1. Kyushu Univ., Grad. Sch. Pharm. Sci.)
Comment()
10:33 AM - 10:56 AM JST(1:33 AM - 1:56 AM UTC)

[3AS-12-06]Determinants of efficient replication origins in vertebrates and their interaction with transcription

○Marie-Noelle Prioleau1, Caroline Doncarli1, Juliette Mandelbrojt1, Jérémy Poulet Benedetti1, Théo Baret1 (1. University Paris Cité, CNRS, Institut Jacques Monod)
Comment()
10:56 AM - 11:13 AM JST(1:56 AM - 2:13 AM UTC)

[3AS-12-07]Dissecting the 3D genome architecture dynamics through single-cell DNA replication profiling

○Ichiro Hiratani1 (1. RIKEN BDR)
Comment()
11:13 AM - 11:15 AM JST(2:13 AM - 2:15 AM UTC)

Conclusion

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